As time passes and Rukia has yet to return to the Soul Society, her Soul Reaper superiors learn about her whereabouts and actions and sentence her to death for performing the illegal act of transferring her powers. Although he is unable to stop Rukia's departure to the Soul Society, Ichigo resolves to rescue her with the aid of several of his spiritually aware classmates, Orihime Inoue, Yasutora Sado, and Uryu Ishida, and the ex-Soul Reapers, Yoruichi Shihoin and Kisuke Urahara. Once at the Soul Society, Ichigo and company battle against the elites of the Soul Reaper military and strive to reach Rukia before her execution. It is revealed that Rukia's execution and Ichigo's rescue attempt both had been manipulated by a high-ranking Soul Reaper, Sosuke Aizen, who was previously believed to have been murdered, as part of a far-reaching plot to take control of the Soul Society. Aizen betrays his fellow Soul Reapers and allies himself with the strongest of the Hollows, the Espadas, whom he enhances. Aizen thus becomes the main antagonist of the series, and the Soul Reapers form an alliance with Ichigo.
At this point, Bleach chronicles the war between the Soul Reapers, the Espadas, and Aizen. After each of the involved's eventual defeats, Ichigo undergoes intense training with his father Isshin who turns out to be a former Soul Reaper to become strong enough to battle Aizen alone. As Aizen is weakened by his battle with Ichigo, a spell that Urahara had previously hidden within him activates and seals him, thus ending the conflict and leaving the Soul Society to imprison him. As a result of using all of his Soul Reaper powers to defeat Aizen, Ichigo loses them and becomes an ordinary human once again.
Seventeen months later, Ichigo meets "Xcution", a group of humans possessing Fullbring powers based on Hollows and want Ichigo to absorb them. Ichigo starts training to regain his Soul Reaper powers by first developing his own Fullbring following the appearance of Shukuro Tsukishima, the former leader of Xcution who is targeting his friends. After developing his Fullbring, Ichigo is betrayed by Xcution's current leader Kugo Ginjo, a former Substitute Soul Reaper who had his memories rewritten to act as Tsukishima's enemy and help Ichigo gain powers to steal them. With help from Soul Society, Ichigo regains his Soul Reapers powers and starts fighting Ginjo's group alongside Soul Society's forces. The Soul Society forces end victorious with Ichigo killing Ginjo and Byakuya presumably killing Tsukishima.
Following these events, A group of Quincies called the "Vandenreich" declare war on the Soul Society. Ichigo once again ventures to Hueco Mundo.